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pentobarbital will reduce the extent or impact of isradipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can minimize panobinostat stages by ~70% and lead to re